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Last update 2007-05 2007-05 2007-05 2007-05 2010-02
Company Bio-Products Laboratory Biotest Pharma GmbH Grifols Kedrion Octapharma
Name of product Vigam Intraglobin® F Flebogamma IG VENA Octagam 5%
Available for Hospital therapy Yes Yes  Yes Yes Yes
Available for Home therapy - not available for home therapy   None Depends on legal situation,  may be used at home in general
IVIG, SCIG or IMIG IVIG IVIG IVIG IVIG IVIG
Patient´s age Adults and pediatrics unlimited   Adults & Children Children and adults
Présentation Liquid ready-to-use solution Liquid Liquid Liquid
Concentration % 5% 5% solution 5% 5% 5%
Content of IgG 95% ≥ 95%   ≥ 99% 95% ≥ 95%
IgG1 65 62% 70.3% 24,3  -  37,2  mg 62,2% ± 2,2
IgG2 29 34% 24.7% 12,4  -  22,1  mg 31,1% ± 2,3
IgG3 6 0.5% 3.1% 0,9  -   1,5  mg 6,1% ± 1,6
IgG4 1 3.5% 2% 0,1  -   0,5  mg 1,2 % ± 0,2
Content of IgA < 0.02% w/w ≤ 2.5 mg/ml <0,05 mg/ml < 0,05 mg/ml ≤ 0.2 mg/mL
Glucose, Maltose,… Sucrose glucose 25 mg   Maltose Maltose 10%
Average dosage for PID Dependant on age and weight of patient initial 0.4 - 0.8 g/kg, followed by 0.2 -0.8 g/kg   0,4 - 0,8 g/kg 0.4 g/kg b.w.
Max. Speed of infusion 3 ml/minute 2.2 mg/ml per hour   40 drops/minute 5 ml/kg/hour
Intervals of infusion for PID Every 2-4 weeks to obtain IgG trough level of at least 4-6 g/L dependent on the individual serum IgG level between 2 and 4 weeks   21-28 days every 3 to 4 weeks
Preserving Vigam® Liquid should be stored in the dark in its carton, between 2° and 8°C.  DO NOT FREEZE.  A short period up to 3 months at 25°C is possible within the shelf-life period. storage in refrigerator (+2 to +8 0C) - shelf-life: 2 years Between +2ºC and +25ºC. Do not freeze. Discard after expiration date. +2C°< T <+8C° Below 25°C
Time for reconstitution N/A   none Ready for use none
Packaging*   containers with 20, 50, 100 or 200 ml   1g/ 20 ml ; 2,5 g/ 50 ml ;  5 g/ 100 ml ; 10 g/ 200 ml 1g, 2.5g, 5g, 10g
* May be different from country to country